Acetylsalicylic acid definition of acetylsalicylic acid by. Bioaccumulation accumulationno information available. Transfer of large quantities of flammables, acids, bases, or other hazardous materials. Applications tn1071 page 3 of 8 experimental acetylsalicylic acid and related substances. The expected concentrations in the samples were chosen in a way to be close to middle range. E29 preparation of aspirin acetylsalicylic acid and thinlayer chromatography of analgesic drugs the task to prepare a pharmaceutical compound and test its purity.
Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention. Aspirin is the most widely used overthecounter drug in the world. Aspirinalso known as acetylsalicylic acidis sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories. Coated, chewable, buffered, and extended release forms are available. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with an inert binding material such as starch. If inhaled if breathed in, move person into fresh air. Jul 27, 2017 acetylsalicylic acid get uptodate information on acetylsalicylic acid side effects, uses, dosage, overdose, pregnancy, alcohol and more. Material safety data sheets the syracuse city school district.
The only other information i know,is that the acetylsalicylic acid reacts with hydroxide ion,from a standardized sodium hydroxide solution. Sds of acetylsalicylic acid, safety data sheets, cas 50782. Material safety data sheet page 1 of 2 acetylsalicylic acid. Aspirinalso known as acetylsalicylic acid is sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories. Basically i think that acetylsalicylic acid isnt very soluble in water because of its polarity. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters 150 feet for liquids and at least 25 meters 75 feet for solids. Material safety data sheet acetylsalicylic acid if inhaled if breathed in, move person into fresh air. For this reason, it is industrially synthesized on a massive scale, producing up. Organic chemistry ii january 30, 20 synthesis of aspirin acetylsalicylic acid using acid and base catalysis. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. Salicylic acid, whose name comes from salix, the willow family of plants, was derived from willow bark extracts.
Contact a licensed professional waste disposal service to dispose of this material. In case of skin contact wash off with soap and plenty of water. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Msds contains all of the information required by those regulations. So aso in the raman shft 550 cm1, there is a shift and this is a ccl bond, which indicates a different composition of the acetylsalicylic acid. Comparative analytical study for determination of acetylsalicylic acid in bulk and in pharmaceutical formulations sahar samir mohammed department of chemistry, college of science, alnahrain university, baghdadiraq. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910. In folk medicine, willow bark teas were used as headache remedies and other tonics. Ac158180000, ac158180025, ac158185000, ac385760000 synonyms. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Synthesis of aspirin acetylsalicylic acid using acid and base catalysis chm 2211c. Buy acetylsalicylic acid 75mg150mg tablets at our pharmacy. See actual entry in rtecs for complete information. Development of a new analytical method for determination of.
Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Product and company identification acetylsalicylic acid. The effect of lowdose acetylsalicylic acid 100 mgday upon bypass patencyrate and clinical course after aortocoronary bypass surgery was investigated in a randomized, placebocontrolled clinical trial. The msds sheet for acetylsalicylic acid estimates its oral, single dose ld50 as 357 mg per kg in humans. O acetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. Oacetylsalicylic acid 2acetoxybenzoic acid aspirin formula. Dec 12, 2005 i know that acetylsalicylic acid isnt very soluble in water.
Safety data sheet chandlergilbert community college. Not all of the mass of an aspirin tablet is acetylsalicylic acid, as there are starch binders added to hold the tablet together. This material is considered hazardous by the osha hazard. The skills by the end of the experiment you should be able to. Acetylsalicylic acid side effects, uses, dosage, overdose. Also,one mol of oh reacts with one mole of acetylsalicylic acid. Ac158180000, ac158180500, ac158185000, ac385760000 synonyms. Excerpt from erg guide 154 substances toxic andor corrosive noncombustible. Salicigen, an extract of willow and poplar bark, has been used as a pain reliever. The first known use of an aspirinlike preparation can be traced to ancient greece and rome.
Acetylsalicylic acid not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Acetylsalicylic acid asa makes the platelets in your blood less sticky. Acetylsalicylic acid is used for the treatment of fever as well as inflammation and pain caused by various conditions such as arthritis, menstrual pain, headache, migraines, muscle. Precautionary statements p261 avoid breathing dust. Abstract a new sensitive colorimetric method for determination of aspirin tablet in aqueous solution. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers j nagelschmitz,1 m blunck,1 j kraetzschmar,1 m ludwig,1 g wensing,1 t hohlfeld2 1bayer healthcare ag, clinical pharmacology, wuppertal, germany. Oacetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever. Sigmaaldrich offers a number of acetylsalicylic acid products. Aspirin is only found in individuals who have consumed this drug.
O acetylsalicylic acid 2acetoxybenzoic acid aspirin formula. Ive tried researching on the net and so far i havent really got it, but i think im onto something. Synthesis of oil of wintergreen cornell center for. How many 80mg aspirin tablets would a 160 pound person have to consume to ingest the estimated ld50 for acetylsalicylic acid. Salicylic acid and its esters are used as food preservatives, in skincare products and other cosmetics, and in topical medicines. Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer. Sixty patients with 143 distal anastomoses of bypasses were randomized, 46 underwent repeat angiography after 4 months. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with.
Acetylsalicylic acid an overview sciencedirect topics. Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Synthesis of acetylsalicylic acid aspirin using acid. Material safety data sheet acetylsalicylic acid product observe all federal, state, and local environmental regulations. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Methyl salicylate may be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus. Specifies the medication aspirin acetylsalicylic acid, aspirin, arthritis foundation safety coated aspirin, bayer aspirin, bayer childrens aspirin, ecotrin, and many others, a drug used for the treatment of arthritis, pain, inflammation, and fever. Pdf multiple targets of salicylic acid and its derivatives in plants. Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally. Synthesis of oil of wintergreen pre lab discussion.
Please note that some chemicals, such as hydrofluoric acid, require use of a special antidote such as calcium gluconate gel and. Safety data sheet northwest missouri state university. In this lab, we synthesized aspirin using both acid catalysis and base catalysis. I know that acetylsalicylic acid isnt very soluble in water. Chapter 7 safe chemical use cornell ehs cornell university. Acetylsalicylic acid solubilty organic chemistry science. Search results for acetylsalicylic acid at sigmaaldrich. Methyl salicylate c6h4 ho cooch3, also known as salicylic acid methyl ester, oil of wintergreen, is a natural product of many species of plants. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid. How many moles of acetylsalicylic acid molarmass 180.
Aspirin material safety data sheet cas no 50782 sdsmsds. Safety data sheet according to 29cfr19101200 and ghs rev. One reagent lane fair lawn, nj 07410 for information in north america, call. Acetylsalicylic acid aspirin, a prodrug to salicylic acid, is made by an entirely different process. Aspirin given shortly after a heart attack decreases the risk of death. E29 preparation of aspirin acetylsalicylic acid and thin. Acetylsalicylic acid is a white crystal or powder that is. Curiously, salicylic acid is also a metabolite of aspirin. Acetylsalicylic acid aspirin not listed not listed ec50 360 mgl 1 h ec50 900 mgl 1 h ec50. In a business making drugs based on, for example, acetylsalicylic acid, a product that has been on the market for well over 100 years, the chances are there is often no new knowledge to be gained from psurs periodic safety update reports and single case handling, yet the dogged reporting and analysis still has to take place in order to. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation.
Section 1 chemical product and company identification. Acetylsalicylic acid aspirin is a nonsteroidal antiinflammatory drug nsaid with properties that inhibit the proinflammatory status of the brain. Synthesis of acetylsalicylic acid dan jones, josh schmidt abstract acetylsalicylic acid, commonly known as aspirin, is considered to be the most successful pharmaceutical product in the world. In this lab, students will analyze aspirin acetylsalicylic acid tablets for the acetylsalicylic acid content, using a volumetric analysis technique called titration. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. Development of a new analytical method for determination of acetylsalicylic and salicylic acids 725 following experimental outline. Other references state that a 10 g dose 143 mgkg may be fatal in humans. First aid measures always seek professional medical attention after first aid measures are provided. Substitute less hazardous chemicals in your experiments whenever possible. Show this safety data sheet to the doctor in attendance. Will likely be mobile in the environment due to its water solubility. If not breathing give artificial respiration consult a physician. Pdf salicylic acid sa is a critical plant hormone that is involved in many.
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